Clonal evolution of pre-malignant B-cells in the absence of AID
![Clonal evolution of pre-malignant B-cells in the absence of AID](/media/1246/476634409e35326bbe123cc33e2d4231.jpg)
Guillermo Rodríguez-Hernández
Centro de Investigación del Cáncer, CIC-IBMCC, lab.13
14/02/2019 to 01/01/0001
Time: 12:30:00
Salón de Actos del Centro de Investigación del Cáncer
Infections during early childhood have been associated to the development of childhood B-cell acute leukemia (B-ALL). We recently showed that natural exposure to infectious pathogen induced development of overt B-ALL in mouse models mimicking the human genetic predisposition to B-ALL. In addition to its role as central effector of somatic hypermutation and class-switch recombination in B-cells, AID contributes to B-cell transformation. Likewise, a recent mouse mod