Feedback loops controlling migration and invasion in healthy and cancerous cells

Cell migration is essential for normal embryogenesis, immune system function and wound healing.   It is often misregulated in disease, such as during cancer metastasis.  It is also extremely complex, involving coordinated actin dynamics, adhesion and mechanosensing.  We are interested in how Rho family GTPases trigger actin assembly, leading to feedback loops and controlling migration.  We have uncovered many