Functional analysis of mammalian gametogenesis.

Gametogenesis is among the most complex and strictly regulated differentiation programme in which a diploid cell give rise to gametes making use of a unique reductional division. Our studies focuses on different macro molecular structures that operates during meiosis, such as the cohesin complex (STAG3), the synaptonemal complex (SIX6OS1), and the spermatoproteasome (PSMA8), which we have ultimately shown its essential role for mammalian fertility. Since a large f