Gasdermin B in Breast Cancer: Unveiling its Janus-Faced Role
Gema Moreno-Bueno
IIB "Alberto Sols" (CSIC-UAM)
The seminar will focus on decoding the role of Gasdermin B (GSDMB) in breast cancer. GSDMB belongs to the gasdermin family of proteins, comprising six members in humans. Generally, these proteins have emerged as final executors of a type of lytic and inflammatory cell death known as pyroptosis; however, other functionalities have also been elucidated. Data from our group have revealed that GSDMB overexpression, found in approximately 60% of HER2-positive breast tumors, could be considered a new prognostic and therapeutic marker. Furthermore, beyond this pro-tumor GSDMB function, our group has recently deciphered a new anti-tumor role for GSDMB, which could be exploited as a novel therapy for cancer treatment through various approaches.