Illuminating the beginning of life
The Schuh lab studies meiosis in mammalian oocytes. In particular, we are interested in how oocytes segregate their chromosomes, and how aneuploidy arises from chromosome segregation errors during the meiotic divisions. Our interests focus on how chromosome architecture changes with advancing maternal age, and how cytoskeletal structures, in particular actin and microtubules, cooperate to drive chromosome segregation in meiosis. I will present our latest research on spindle assembly and causes of aneuploidy in female meiosis.