Unveiling unexpected tumor suppressor functions for Vav3 in nonsmall cell lung cancer.

Rho GTPases regulate a number of protumorigenic functions in cancer cells, including cytoskeletal organization, cell migration, proliferation, and cell survival. Consistent with this, a large plethora of cell- and animal model-based studies have shown that the elimination of most of these proteins contributes negatively to the fitness of cancer cells. Likewise, the recent characterization of the genome of cancer cells has revealed the presence at low frequency of